Thanksgiving is a really big deal in my family, and I've always brewed a beer to bring along.
My advice is, don't brew something heavy or too high in alcohol. The first time I brewed for Thanksgiving I did NB's Surly Bender clone. It was a great beer, but just too filling/intoxicating. Folks had one or two then switched to commercial beers. (Heineken, Sam Adams, etc.)
Since then I've always tried to keep the ABV under 5%, and folks have said they prefer this. Last year I brewed a 3.8ish% bitter, we killed the corny that day. This year I'm planning a stout porter, should be about 4.2%. Planning on serving this one on cask, we'll see how it goes...